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This paper presents a ECG monitoring system design based on Zigbee technology; Use Zigbee technology and STM32W108 ARM chip to design the hardware circuits of acquisition nodes and sink node, and use C language to write their software, to realize human ECG acquisition and wireless transmission; Through the PC for data monitoring and analysis based on the ECG monitoring user interface designed by the Labview software of National Instruments Company. The experiments show that, the monitoring network achieves relatively more precise ECG acquisition, monitoring and analysis of heart rate and ECG spectrum. The system has certain application value in the family guardianship field.